The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core
نویسندگان
چکیده
منابع مشابه
The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core.
Inosine triphosphate pyrophosphatase (ITPA), a key enzyme involved in maintaining the purity of cellular nucleoside triphosphate pools, specifically recognizes inosine triphosphate and xanthosine triphosphate (including the deoxyribose forms) and detoxifies them by catalyzing the hydrolysis of a phosphoanhydride bond, releasing pyrophosphate. This prevents their inappropriate use as substrates ...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2013
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2013.03.007